Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2006

Graham Daniel B, Bell Michael P, Huntoon Catherine J, Griffin Matthew D, Tai Xuguang, Singer Alfred, McKean David J

Abstract excerpt

The differentiation of double-positive (DP) CD4(+)CD8(+) thymocytes to single-positive CD4(+) or CD8(+) T cells is regulated by signals that are initiated by coengagement of the Ag (TCR) and costimulatory receptors. CD28 costimulatory receptors, which augment differentiation and antiapoptotic responses in mature T lymphocytes, have been reported to stimulate both differentiation and apoptotic responses in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apoptosis Regulatory Proteins

Share to Bcl-2-Like Protein 11

Share to CD28 Antigens

Share to Extracellular Signal-Regulated MAP Kinases

Share to Lectins, C-Type

Share to Thymus Gland

Source

Identifiers

PMID: 17056536
DOI: 10.4049/jimmunol.177.9.6098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.PMID 17056536Read ↗

Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging.Semantic proximity Read ↗

CD80, CD86 and CD40 Provide Accessory Signals in a Multiple‐Step T‐Cell Activation ModelSemantic proximity Read ↗

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.Semantic proximity Read ↗

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.Semantic proximity Read ↗

A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen.Semantic proximity Read ↗

B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.Semantic proximity Read ↗

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).Semantic proximity Read ↗

CD8 lineage commitment in the absence of CD8.Semantic proximity Read ↗

Chagasic Patients Lack CD28 Expression on Many of Their Circulating T LymphocytesSemantic proximity Read ↗

T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement.Semantic proximity Read ↗

Preferential elimination of CD28+ T cells in systemic lupus erythematosus (SLE) and the relation with activation-induced apoptosis.Semantic proximity Read ↗

Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.