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Article

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.

International immunology - 1 May 1993

Lake R A, O'Hehir R E, Verhoef A, Lamb J R

Abstract excerpt

The induction of non-responsiveness in specific clones of T cells in vivo might be expected to reverse immunologically mediated disease processes. With this goal in mind, experiments in vitro with cloned T cells have investigated the mechanisms of induction of anergy. Resting T cells can be funct...

Topics

Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Base Sequence
CD28 Antigens
Clone Cells
DNA
Down-Regulation
Humans
Immune Tolerance
Lymphocyte Activation
Molecular Sequence Data
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA, Messenger

T-Lymphocytes

Source

Identifiers

PMID: 8391307
DOI: 10.1093/intimm/5.5.461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8391307-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.PMID 8391307Read ↗

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