Article
Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation.
Molecular and cellular biology - 1 Jul 2009
Dodson Lindzy F, Boomer Jonathan S, Deppong Christine M, Shah Dulari D, Sim Julia, Bricker Traci L, Russell John H, Green Jonathan M
Abstract excerpt
Despite extensive study, the role of phosphatidylinositol 3-kinase (PI3-kinase) activation in CD28 function has been highly contentious. To definitively address this question, we generated knock-in mice expressing mutations in two critical domains of the cytoplasmic tail of CD28. Mutation of the proximal tyrosine motif interrupted PI3-kinase binding and prevented CD28-dependent phosphorylation of protein kinase B...
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