Article
A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen.
International immunology - 1 Oct 2004
Gao Jian-Xin, Chang Xing, Zheng Xincheng, Wen Jing, Yin Lijie, Du Peishuang, Zheng Pan, Liu Yang
Abstract excerpt
Recent work demonstrates that costimulatory molecules play a critical role for clonal deletion of autoreactive T cells in the thymus. The role of CD28 in the survival of autoreactive T cells in the periphery, however, has not been reported. Here we demonstrate that while mutation of the CD28 gene consistently increased the burden of autoreactive T cells in the thymus, such an increase was not always found in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.