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Article

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.

European journal of immunology - 1 Jun 2006

Manzotti Claire N, Liu Michael K P, Burke Fiona, Dussably Laure, Zheng Yong, Sansom David M

Abstract excerpt

CD80 and CD86 have the capacity to either stimulate or inhibit T cell responses through their receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Blockade of CD80 and CD86 in autoimmune disease settings has revealed distinct outcomes, yet the differential functions of CD80 and CD86 are still unclear. We have studied the ability of individual ligands to stimulate primary responses in human...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16708397
DOI: 10.1002/eji.200535170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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