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Article

B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004

Zheng Xincheng, Gao Jian-Xin, Chang Xing, Wang Yin, Liu Yan, Wen Jing, Zhang Huiming, Zhang Jian, Liu Yang, Zheng Pan

Abstract excerpt

Costimulatory molecules play critical roles in the induction and effector function of T cells. More recent studies reveal that costimulatory molecules enhance clonal deletion of autoreactive T cells as well as generation and homeostasis of the CD25(+)CD4(+) regulatory T cells. However, it is unclear whether the costimulatory molecules play any role in the proliferation and differentiation of T cells before they...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15294937
DOI: 10.4049/jimmunol.173.4.2253

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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