Article
B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2004
Zheng Xincheng, Gao Jian-Xin, Chang Xing, Wang Yin, Liu Yan, Wen Jing, Zhang Huiming, Zhang Jian, Liu Yang, Zheng Pan
Abstract excerpt
Costimulatory molecules play critical roles in the induction and effector function of T cells. More recent studies reveal that costimulatory molecules enhance clonal deletion of autoreactive T cells as well as generation and homeostasis of the CD25(+)CD4(+) regulatory T cells. However, it is unclear whether the costimulatory molecules play any role in the proliferation and differentiation of T cells before they...
Topics
- Animals
- Antigens, CD
- B7-1 Antigen
- B7-2 Antigen
- Blotting, Western
- CD28 Antigens
- Cell Differentiation
- Cell Division
- Cell Survival
- DNA-Binding Proteins
- Flow Cytometry
- Genes, T-Cell Receptor
- Immunohistochemistry