Article
Role of the sigma factor in transcription initiation in the absence of core RNA polymerase.
Cell - 20 Oct 2006
Hsu Hsin-Hsien, Chung Kuei-Min, Chen Tsung-Ching, Chang Ban-Yang
Abstract excerpt
Sigma factors (sigmas) are bacterial transcription factors that bind core RNA polymerase (RNAP) and direct transcription initiation at cognate promoter sites. However, most of their functions have been investigated in the context of RNAP. This has made the exact function of sigma, and the importance of core RNAP in modulating sigma function, ambiguous. Here we identify a Bacillus subtilis mutant sigma(A) that is...
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