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Article

RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase.

Nucleic acids research - 2 Nov 2018

Sudalaiyadum Perumal Ayyappasamy, Vishwakarma Rishi Kishore, Hu Yangbo, Morichaud Zakia, Brodolin Konstantin

Abstract excerpt

The transcriptional activator RbpA associates with Mycobacterium tuberculosis RNA polymerase (MtbRNAP) during transcription initiation, and stimulates formation of the MtbRNAP-promoter open complex (RPo). Here, we explored the influence of promoter motifs on RbpA-mediated activation of MtbRNAP containing the stress-response σB subunit. We show that both the 'extended -10' promoter motif (T-17G-16T-15G-14) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30102406
DOI: 10.1093/nar/gky714
PMCID: PMC6212719

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