Article
A fork junction DNA-protein switch that controls promoter melting by the bacterial enhancer-dependent sigma factor.
The EMBO journal - 1 Jul 1999
Guo Y, Wang L, Gralla J D
Abstract excerpt
Results of binding assays using DNA fork junction probes indicate that sigma 54 contains multiple determinants that regulate melting to allow RNA polymerase to remain in closed promoter complexes in order to respond to enhancers. Gel mobility shift studies indicate that the -12 promoter element and parts of sigma 54 act together to form a molecular switch that controls melting. The DNA sequences and the sigma 54...
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