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Article

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.

Journal of molecular biology - 5 Jan 2007

Manon Florence, Favier Adrien, Núñez Gabriel, Simorre Jean-Pierre, Cusack Stephen

Abstract excerpt

NOD1 is a cytosolic signalling host pattern-recognition receptor composed of a caspase-activating and recruitment domain (CARD), a nucleotide-binding and oligomerization domain (NOD) and leucine-rich repeats. It plays a crucial role in innate immunity by activating the NF-kappaB pathway via its downstream effector the kinase RICK (RIP2) following the recognition of a specific bacterial ligand. RICK is recruited...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Magnetic Resonance, Biomolecular

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Source

Identifiers

PMID: 17054981
DOI: 10.1016/j.jmb.2006.09.067

Genes

NOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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