Article
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.
The Journal of biological chemistry - 16 Feb 2001
Ogura Y, Inohara N, Benito A, Chen F F, Yamaoka S, Nunez G
Abstract excerpt
Apaf-1 and Nod1 are members of a protein family, each of which contains a caspase recruitment domain (CARD) linked to a nucleotide-binding domain, which regulate apoptosis and/or NF-kappaB activation. Nod2, a third member of the family, was identified. Nod2 is composed of two N-terminal CARDs, a nucleotide-binding domain, and multiple C-terminal leucine-rich repeats. Although Nod1 and Apaf-1 were broadly...
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