Article
Characterization of Mengo virus neutralization epitopes.
Virology - 1 Mar 1991
Boege U, Kobasa D, Onodera S, Parks G D, Palmenberg A C, Scraba D G
Abstract excerpt
A set of four monoclonal antibodies which neutralized the infectivity of Mengo virus was used to select 20 non-neutralizable (escape) mutants. Altered amino acids were identified by sequence analyses of the capsid-coding regions of the mutant virus genomes. Mutations were found predominantly in p...
Topics
- Animals
- Antibodies, Monoclonal
- Capsid
- Codon
- Epitopes
- L Cells
- Mengovirus
- Mice
- Models, Molecular
- Models, Theoretical
- Mutation
- Neutralization Tests
- Protein Conformation