Antigenic structure of human hepatitis A virus defined by analysis of escape mutants selected against murine monoclonal antibodies.

doi:10.1128/JVI.66.4.2208-2216.1992

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Article

Antigenic structure of human hepatitis A virus defined by analysis of escape mutants selected against murine monoclonal antibodies.

Journal of virology - 1 Apr 1992

Ping L H, Lemon S M

Abstract excerpt

We examined the antigenic structure of human hepatitis A virus (HAV) by characterizing a series of 21 murine monoclonal-antibody-resistant neutralization escape mutants derived from the HM175 virus strain. The escape phenotype of each mutant was associated with reduced antibody binding in radioim...

Topics

Animals
Antibodies, Monoclonal
Antigens, Viral
Cell Line
Cross Reactions
Hepatovirus
Mice
Mutation
Neutralization Tests

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