Article
Neutralization epitopes of human rhinovirus type 2.
The Journal of general virology - 1 Jun 1990
Appleyard G, Russell S M, Clarke B E, Speller S A, Trowbridge M, Vadolas J
Abstract excerpt
Fourteen neutralizing monoclonal antibodies recognizing human rhinovirus (HRV) type 2 have been used to select a total of 51 virus escape mutants. Cross-resistance analysis of the mutants, together with RNA sequencing and identification of amino acid substitutions, have revealed three neutralization sites on the virus surface. Two of these appear to correspond to the NIm-IA and NIm-II sites described for HRV-type...
Topics
- Amino Acids
- Antibodies, Monoclonal
- Antigens, Viral
- Base Sequence
- Epitopes
- Humans
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Rhinovirus