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Article

Naturally occurring mutations within 39 amino acids in the envelope glycoprotein of maedi-visna virus alter the neutralization phenotype.

Journal of virology - 1 Oct 1999

Skraban R, Matthíasdóttir S, Torsteinsdóttir S, Agnarsdóttir G, Gudmundsson B, Georgsson G, Meloen R H, Andrésson O S, Staskus K A, Thormar H, Andrésdóttir V

Abstract excerpt

Infectious molecular clones have been isolated from two maedi-visna virus (MVV) strains, one of which (KV1772kv72/67) is an antigenic escape mutant of the other (LV1-1KS1). To map the type-specific neutralization epitope, we constructed viruses containing chimeric envelope genes by using KV1772kv72/67 as a backbone and replacing various parts of the envelope gene with equivalent sequences from LV1-1KS1. The...

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Identifiers

PMID: 10482555
DOI: 10.1128/JVI.73.10.8064-8072.1999
PMCID: PMC112822

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