Article
Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118.
Archives of virology - 1 Jan 1998
Kikuchi M, Yoshimatsu K, Arikawa J, Yoshida R, Yoo Y C, Isegawa Y, Yamanishi K, Tono-oka S, Azuma I
Abstract excerpt
Neutralizing monoclonal antibody (MAb) escape mutants of Hantaan virus were generated using MAbs to envelope protein G1 (16D2) and G2 (11E10). The mutant viruses (mu16D2 and mu11E10), lacked reactivity only to the selecting MAb, or a MAb belonging to the same antigenic site. Both mutants had a si...
Topics
- Amino Acid Substitution
- Animals
- Animals, Newborn
- Antibodies, Monoclonal
- Antigens, Viral
- Binding Sites
- Chlorocebus aethiops
- Epitopes
- Female
- Hantaan virus
- Mice
- Mice, Inbred BALB C
- Mutation
- Neutralization Tests
- Pregnancy
- Sequence Analysis
- Specific Pathogen-Free Organisms
- Vero Cells