Article
A single-amino-acid substitution in the P2 domain of VP1 of murine norovirus is sufficient for escape from antibody neutralization.
Journal of virology - 1 Nov 2007
Lochridge Vance P, Hardy Michele E
Abstract excerpt
Noroviruses cause epidemic outbreaks of acute viral gastroenteritis worldwide, and the number of reported outbreaks is increasing. Human norovirus strains do not grow in cell culture. However, murine norovirus (MNV) replicates in the RAW 264.7 macrophage cell line and thus provides a tractable model to investigate norovirus interactions with host cells. Epitopes recognized by monoclonal antibodies (MAbs) against...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Epitope Mapping
- Epitopes
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Norovirus
- Norwalk virus