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Article

Identification of operationally overlapping and independent cross-reactive neutralization regions on human rotavirus VP4.

The Journal of general virology - 1 Nov 1990

Kobayashi N, Taniguchi K, Urasawa S

Abstract excerpt

Cross-reactive neutralization epitopes on VP4 of human rotavirus (HRV) were analyzed by the use of VP4-specific neutralizing monoclonal antibodies (N-MAbs) and MAb-resistant mutants. Seven anti-VP4 N-MAbs obtained in this study by using HRV serotypes 1 and 3 as immunizing antigens showed a variety of cross-reactivity patterns to 20 HRV strains with different serotype specificity in neutralization tests and a...

Topics

Animals
Antibody Specificity
Capsid
Capsid Proteins
Cross Reactions
Enzyme-Linked Immunosorbent Assay
Epitopes
Humans
Hybridomas
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neutralization Tests

Peptide Mapping

Rotavirus

Source

Identifiers

PMID: 1701477
DOI: 10.1099/0022-1317-71-11-2615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1701477-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Identification of operationally overlapping and independent cross-reactive neutralization regions on human rotavirus VP4.PMID 1701477Read ↗

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