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Article

Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.

Biochemistry - 23 Mar 2004

Kovarik Zrinka, Radić Zoran, Berman Harvey A, Simeon-Rudolf Vera, Reiner Elsa, Taylor Palmer

Abstract excerpt

Selective mutants of mouse acetylcholinesterase (AChE; EC 3.1.1.7) phosphonylated with chiral S(P)- and R(P)-cycloheptyl, -3,3-dimethylbutyl, and -isopropyl methylphosphonyl thiocholines were subjected to reactivation by the oximes HI-6 and 2-PAM and their reactivation kinetics compared with wild-type AChE and butyrylcholinesterase (EC 3.1.1.8). Mutations in the choline binding site (Y337A, Y337A/F338A) or...

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Source

Identifiers

PMID: 15023072
DOI: 10.1021/bi036191a

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.PMID 15023072Read ↗

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