Article

A 5’ UTR Mutation Contributes To Down-Regulation Of Bbs7 In The Berlin Fat Mouse

2022-03-02

Abstract excerpt

The Bardet Biedl syndrome 7 ( Bbs7 ) gene was identified as the most likely candidate gene causing juvenile obesity in the Berlin Fat Mouse Inbred (BFMI) line. Bbs7 is significantly lower expressed in brain, adipose tissue, and liver of BFMI mice compared to lean C57BL/6NCrl (B6N) mice. DNA sequence comparison between BFMI and B6N revealed 16 sequence variants in the Bbs7 promoter region. Here, we tested if these...

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Literature Corpus work: 9ac78af2-c303-56e5-964a-9a10bdf8f6e9
DOI: 10.21203/rs.3.rs-1384685/v1

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