Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling.

The Journal of endocrinology - 1 Jun 2016

Wiemerslage Lyle, Gohel Priya A, Maestri Giulia, Hilmarsson Torfi G, Mickael Michel, Fredriksson Robert, Williams Michael J, Schiöth Helgi B

Abstract excerpt

Transmembrane protein 18 (TMEM18) is an ill-described, obesity-related gene, but few studies have explored its molecular function. We found single-nucleotide polymorphism data, suggesting that TMEM18 may be involved in the regulation/physiology of metabolic syndrome based on associations with insulin, homeostatic model assessment-β (HOMAβ), triglycerides, and blood sugar. We then found an ortholog in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Fat Body

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Genes, Insect

Share to Glucagon

Share to Insulin

Share to Obesity

Source

Identifiers

PMID: 27029472
DOI: 10.1530/JOE-16-0040

Genes

TMEM18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling.PMID 27029472Read ↗

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG.Semantic proximity Read ↗

The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.Semantic proximity Read ↗

Diabetes-associated <i>MYT1</i> and <i>ST18</i> regulate human beta-cell insulin secretion and survival via other diabetes-risk genesSemantic proximity Read ↗

Loss and gain of function experiments implicate TMEM18 as a mediator of the strong association between genetic variants at human Chromosome 2p25.3 and obesitySemantic proximity Read ↗

MicroRNA-188 regulates aging-associated metabolic phenotype.Semantic proximity Read ↗

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feedingSemantic proximity Read ↗

The association between polymorphisms near TMEM18 and the risk of obesity: a meta-analysis.Semantic proximity Read ↗

A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1.Semantic proximity Read ↗

miR-184 Regulates Pancreatic β-Cell Function According to Glucose MetabolismSemantic proximity Read ↗

Contribution of circulating Mfge8 to human T2DM and cardiovascular disease.Semantic proximity Read ↗

Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.Semantic proximity Read ↗

UPLC-ESI-MS based lipidomics revealed novel biomarkers in insulin receptor knockdown induced type 2 diabetes model of DrosophilaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.