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Article

Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity.

Obesity (Silver Spring, Md.) - 1 Feb 2022

Day Samantha E, Traurig Michael, Kumar Pankaj, Piaggi Paolo, Koroglu Cigdem, Kobes Sayuko, Hanson Robert L, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: This study aimed to identify genetic variants enriched in Southwest American Indian (SWAI) individuals that associate with BMI. METHODS: Whole genome sequencing data (n = 296) were used to identify potentially functional variants that are common in SWAI individuals (minor allele frequency ≥10%) but rare in other ethnic groups (minor allele frequency < 0.1%). Enriched variants were tested for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35043601
DOI: 10.1002/oby.23359
PMCID: PMC9304561

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