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Article

Effect of the VKORC1 genotype on warfarin dose requirements in Japanese pediatric patients.

Drug metabolism and pharmacokinetics - 1 Jun 2011

Kato Yuya, Ichida Fukiko, Saito Kazuyoshi, Watanabe Kazuhiro, Hirono Keiichi, Miyawaki Toshio, Yoshimura Naoki, Horiuchi Isao, Taguchi Masato, Hashimoto Yukiya

Abstract excerpt

The primary aim of the present study was to evaluate the effect of the genotype of vitamin K epoxide reductase complex 1 (VKORC1) on warfarin dose requirements in Japanese pediatric patients. Forty-eight pediatric patients (0.42-19.25 years old) in whom stable anticoagulation was achieved by warfarin were enrolled in this study, and the polymorphic alleles of VKORC1 and CYP2C9 were determined for each subject....

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Identifiers

PMID: 21273734
DOI: 10.2133/dmpk.DMPK-10-NT-082

Genes

VKORC1

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Effect of the VKORC1 genotype on warfarin dose requirements in Japanese pediatric patients.PMID 21273734Read ↗

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