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Article

The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response.

Infection and immunity - 1 Dec 2006

Kurtz Sherry, McKinnon Karen P, Runge Marschall S, Ting Jenny P-Y, Braunstein Miriam

Abstract excerpt

The SecA protein is present in all bacteria, and it is a central component of the general Sec-dependent protein export pathway. An unusual property of Mycobacterium tuberculosis is the presence of two SecA proteins: SecA1, the essential "housekeeping" SecA, and SecA2, the accessory secretion factor. Here, we report that a DeltasecA2 mutant of M. tuberculosis was defective for growth in the early stages of...

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Source

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Identifiers

PMID: 17030572
DOI: 10.1128/IAI.01022-06
PMCID: PMC1698048

Genes

NOS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response.PMID 17030572Read ↗

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