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Article

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

1 Aug 2007

Abstract excerpt

The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a component of a virulence-associated protein secretion system, enhanced the apoptosis of infected macrophages by diminishing secretion of mycobacterial superoxide dismutase. Deletion of secA2 markedly...

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PMID: 17671656
DOI: 10.1172/jci31947

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