Article
The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1.
The Journal of biological chemistry - 10 Apr 2009
Rigel Nathan W, Gibbons Henry S, McCann Jessica R, McDonough Justin A, Kurtz Sherry, Braunstein Miriam
Abstract excerpt
In bacteria, the majority of exported proteins are transported by the general Sec pathway from their site of synthesis in the cytoplasm across the cytoplasmic membrane. The essential SecA ATPase powers this Sec-mediated export. Mycobacteria possess two nonredundant SecA homologs: SecA1 and SecA2. In pathogenic Mycobacterium tuberculosis and the nonpathogenic model mycobacterium Mycobacterium smegmatis, SecA1 is...
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