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Article

Suppressor analysis reveals a role for SecY in the SecA2-dependent protein export pathway of Mycobacteria.

Journal of bacteriology - 1 Oct 2013

Ligon Lauren S, Rigel Nathan W, Romanchuk Artur, Jones Corbin D, Braunstein Miriam

Abstract excerpt

All bacteria use the conserved Sec pathway to transport proteins across the cytoplasmic membrane, with the SecA ATPase playing a central role in the process. Mycobacteria are part of a small group of bacteria that have two SecA proteins: the canonical SecA (SecA1) and a second, specialized SecA (SecA2). The SecA2-dependent pathway exports a small subset of proteins and is required for Mycobacterium tuberculosis...

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Identifiers

PMID: 23913320
DOI: 10.1128/JB.00630-13
PMCID: PMC3807457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppressor analysis reveals a role for SecY in the SecA2-dependent protein export pathway of Mycobacteria.PMID 23913320Read ↗

Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathwaySemantic proximity Read ↗

The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1.Semantic proximity Read ↗

Two nonredundant SecA homologues function in mycobacteria.Semantic proximity Read ↗

Modeling the effects of prl mutations on the Escherichia coli SecY complex.Semantic proximity Read ↗

Protein export by the mycobacterial SecA2 system is determined by the preprotein mature domain.Semantic proximity Read ↗

PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains.Semantic proximity Read ↗

SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosisSemantic proximity Read ↗

A new genetic selection identifies essential residues in SecG, a component of the Escherichia coli protein export machinery.Semantic proximity Read ↗

Screening a library of temperature-sensitive mutants to identify secretion factors in Staphylococcus aureusSemantic proximity Read ↗

Genetic analysis of SecY: additional export-defective mutations and factors affecting their phenotypes.Semantic proximity Read ↗

The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response.Semantic proximity Read ↗

Sec2 protein contains a coiled-coil domain essential for vesicular transport and a dispensable carboxy terminal domain.Semantic proximity Read ↗

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