Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells.

BMC genomics - 9 May 2015

Mendum Tom A, Wu Huihai, Kierzek Andrzej M, Stewart Graham R

Abstract excerpt

BACKGROUND: Mycobacterium tuberculosis continues to kill more people than any other bacterium. Although its archetypal host cell is the macrophage, it also enters, and survives within, dendritic cells (DCs). By modulating the behaviour of the DC, M. tuberculosis is able to manipulate the host's immune response and establish an infection. To identify the M. tuberculosis genes required for survival within DCs we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Wall
Share to Cholesterol
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Transposable Elements

Share to Lipid Metabolism

Share to Mycobacterium tuberculosis

Share to Phagosomes

Share to Reactive Nitrogen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 25956932
DOI: 10.1186/s12864-015-1569-2
PMCID: PMC4425887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells.PMID 25956932Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1Semantic proximity Read ↗

ESX/type VII secretion systems of mycobacteria: Insights into evolution, pathogenicity and protectionSemantic proximity Read ↗

Mechanisms of immune evasion by Mycobacterium tuberculosis : the impact of T7SS and cell wall lipids on host defensesSemantic proximity Read ↗

Conserved and specialized functions of Type VII secretion systems in non-tuberculous mycobacteriaSemantic proximity Read ↗

ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosisSemantic proximity Read ↗

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulenceSemantic proximity Read ↗

Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targetsSemantic proximity Read ↗

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.Semantic proximity Read ↗

Comprehensive analysis of iron utilization by Mycobacterium tuberculosis.Semantic proximity Read ↗

ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial ProteinsSemantic proximity Read ↗

Type VII Secretion: A Highly Versatile Secretion SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.