Article

Ebselen attenuates mycobacterial virulence through inhibition of ESX-1 secretion

2019-11-02

Abstract excerpt

<h4>ABSTRACT</h4> The type VII secretion system ESX-1 mediates virulence in Mycobacterium tuberculosis and Mycobacterium marinum . We find that in M. marinum , the synthetic organoselenium compound ebselen inhibits secretion of ESAT-6, a major ESX-1 substrate. We find that ebselen inhibits the in vitro activity of the ESX-1 AAA+ ATPase EccA1, which potentiates ESX-1 substrate secretion and function. Ebselen m...

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Literature Corpus work: 4d20d52a-6959-53cf-a025-531fb71d095e
DOI: 10.1101/828574

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