Article
Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker.
Differentiation; research in biological diversity - 1 Sept 1991
Nikitin AYu, Lennartz K, Pozharisski K M, Rajewsky M F
Abstract excerpt
Spontaneous myogenic differentiation was observed in 2 out of 15 cases when cells from schwannomas induced in the offspring of BDIX rats by transplacental exposure to N-ethyl-N-nitrosourea (EtNU) were grown in monolayer culture following fluorescence-activated cell sorting with monoclonal antibod...
Topics
- Animals
- Cell Differentiation
- Cells, Cultured
- Immunohistochemistry
- Muscles
- Mutation
- Neoplasm Transplantation
- Neurilemmoma
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogenes