Article
Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.
Cancer research - 1 Oct 2006
Moreno-Bueno Gema, Cubillo Eva, Sarrió David, Peinado Héctor, Rodríguez-Pinilla Socorro María, Villa Sonia, Bolós Victoria, Jordá Mireia, Fabra Angels, Portillo Francisco, Palacios José, Cano Amparo
Abstract excerpt
The transcription factors Snail, Slug, and bHLH E47 have been recently described as direct repressors of E-cadherin and inducers of epithelial-mesenchymal transition (EMT) and invasion when overexpressed in epithelial cells. Although a role of those factors in tumor progression and invasion has been proposed, whether the different repressors play distinct or redundant roles in the tumorigenic process has not been...
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