Article
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.
Nature cell biology - 1 Feb 2000
Batlle E, Sancho E, Francí C, Domínguez D, Monfar M, Baulida J, García De Herreros A
Abstract excerpt
The adhesion protein E-cadherin plays a central part in the process of epithelial morphogenesis. Expression of this protein is downregulated during the acquisition of metastatic potential at late stages of epithelial tumour progression. There is evidence for a transcriptional blockage of E-cadherin gene expression in this process. Here we show that the transcription factor Snail, which is expressed by fibroblasts...
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