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Article

Tumor-associated E-cadherin mutations do not induce Wnt target gene expression, but affect E-cadherin repressors.

Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2004

Laux Holger, Tomer Raju, Mader Michael T, Smida Jan, Budczies Jan, Kappler Roland, Hahn Heidi, Blöchinger Michaela, Schnitzbauer Udo, Eckardt-Schupp Friederike, Höfler Heinz, Becker Karl-Friedrich

Abstract excerpt

E-cadherin is a cell-cell adhesion molecule and tumor invasion suppressor gene that is frequently altered in human cancers. It interacts through its cytoplasmic domain with beta-catenin which in turn interacts with the Wnt (wingless) signaling pathway. We have compared the effects of different tumor-derived E-cadherin variants with those of normal E-cadherin on Wnt signaling and on genes involved in epithelial...

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Identifiers

PMID: 15311212
DOI: 10.1038/labinvest.3700158

Genes

SFRP1
SNAI1
SNAI2
TCF3
TWIST1
ZEB1
ZEB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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