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Article

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers

1 Jan 2009

Abstract excerpt

Epithelial-mesenchymal-transition (EMT) is a crucial process during morphogenesis of multi-cellular organisms. EMT not only is a normal developmental process but also plays a role in tumor invasion and metastasis. Indeed, molecules involved in EMT, such as the transcription factor and E-cadherin repressor Slug (SNAI2), have recently been demonstrated to be important for cancer cells to down-regulate epithelial...

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PMID: 19273255
DOI: 10.2741/3433

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