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Article

The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells

10 Feb 2006

Abstract excerpt

Claudin-1 is an integral membrane protein component of tight junctions. The Snail family of transcription factors are repressors that play a central role in the epithelial-mesenchymal transition, a process that occurs during cancer progression. Snail and Slug members are direct repressors of E-cadherin and act by binding to the specific E-boxes of its proximal promoter. In the present study, we demonstrate that...

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PMID: 16232121
DOI: 10.1042/bj20050591

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Related research

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The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cellsPMID 16232121Read ↗

Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.Semantic proximity Read ↗

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Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.Semantic proximity Read ↗

Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.Semantic proximity Read ↗

The Transcription Factor Snail Induces Tumor Cell Invasion through Modulation of the Epithelial Cell Differentiation ProgramSemantic proximity Read ↗

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.Semantic proximity Read ↗

The role of Snail1 transcription factor in colorectal cancer progression and metastasisSemantic proximity Read ↗

Dysregulated expression of claudins in cancer (Review)Semantic proximity Read ↗

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.Semantic proximity Read ↗

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.Semantic proximity Read ↗

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