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Article

Involvement of members of the cadherin superfamily in cancer.

Cold Spring Harbor perspectives in biology - 1 Dec 2009

Berx Geert, van Roy Frans

Abstract excerpt

We review the role of cadherins and cadherin-related proteins in human cancer. Cellular and animal models for human cancer are also dealt with whenever appropriate. E-cadherin is the prototype of the large cadherin superfamily and is renowned for its potent malignancy suppressing activity. Different mechanisms for inactivating E-cadherin/CDH1 have been identified in human cancers: inherited and somatic mutations,...

Topics

Cadherins
Gene Expression Regulation, Neoplastic
Humans
Multigene Family
Mutation
Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20457567
DOI: 10.1101/cshperspect.a003129
PMCID: PMC2882122

Genes

CDH1
CDH13
CDH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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