Article
Snail and slug play distinct roles during breast carcinoma progression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2006
Côme Christophe, Magnino Fabrice, Bibeau Frédéric, De Santa Barbara Pascal, Becker Karl Friedrich, Theillet Charles, Savagner Pierre
Abstract excerpt
PURPOSE: Carcinoma progression is linked to a partially dedifferentiated epithelial cell phenotype. As previously suggested, this regulation could involve transcription factors, Snail and Slug, known to promote epithelial-mesenchymal transitions during development. Here, we investigate the role of Snail and Slug in human breast cancer progression. EXPERIMENTAL DESIGN: We analyzed Snail, Slug, and E-cadherin RNA...
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