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Article

The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.

PloS one - 1 Jan 2011

Dhasarathy Archana, Phadke Dhiral, Mav Deepak, Shah Ruchir R, Wade Paul A

Abstract excerpt

The transcriptional repressors Snail and Slug are situated at the core of several signaling pathways proposed to mediate epithelial to mesenchymal transition or EMT, which has been implicated in tumor metastasis. EMT involves an alteration from an organized, epithelial cell structure to a mesench...

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Source

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Identifiers

PMID: 22028892
DOI: 10.1371/journal.pone.0026514
PMCID: PMC3197668

Genes

TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22028892-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer.PMID 22028892Read ↗

EMT associated transcription factors Slug and Snail demonstrate specific expression patterns in breast cancer subtypes, involving tumor or stroma components and correlating with proliferation status and complex clinical prognosisSemantic proximity Read ↗

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1Semantic proximity Read ↗

Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.Semantic proximity Read ↗

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional RegulationSemantic proximity Read ↗

Unresolved Complexity in the Gene Regulatory Network Underlying EMTSemantic proximity Read ↗

The Role of Snail in EMT and TumorigenesisSemantic proximity Read ↗

Defining the E-Cadherin Repressor Interactome in Epithelial-Mesenchymal Transition: The PMC42 Model as a Case StudySemantic proximity Read ↗

Snail and Slug Promote Epithelial-Mesenchymal Transition through β-Catenin–T-Cell Factor-4-dependent Expression of Transforming Growth Factor-β3Semantic proximity Read ↗

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transitionSemantic proximity Read ↗

Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast CancerSemantic proximity Read ↗

Establishment of a TGFβ-Induced Post-Transcriptional EMT Gene SignatureSemantic proximity Read ↗

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancersSemantic proximity Read ↗

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