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Article

The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.

Nature cell biology - 1 Feb 2000

Cano A, Pérez-Moreno M A, Rodrigo I, Locascio A, Blanco M J, del Barrio M G, Portillo F, Nieto M A

Abstract excerpt

The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of...

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PMID: 10655586
DOI: 10.1038/35000025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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