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Article

Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.

Cell - 6 Oct 2006

Rothenfluh Adrian, Threlkeld Robert J, Bainton Roland J, Tsai Linus T-Y, Lasek Amy W, Heberlein Ulrike

Abstract excerpt

In most organisms, low ethanol doses induce increased activity, while high doses are sedating. To investigate the underlying mechanisms, we isolated Drosophila mutants with altered ethanol responsiveness. Mutations in white rabbit (whir), disrupting RhoGAP18B, are strongly resistant to the sedating effects of ethanol. This resistance can be suppressed by reducing the levels of Rho1 or Rac, implicating these...

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Identifiers

PMID: 17018286
DOI: 10.1016/j.cell.2006.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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