Article
Rsu1 regulates ethanol consumption in Drosophila and humans.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2015
Ojelade Shamsideen A, Jia Tianye, Rodan Aylin R, Chenyang Tao, Kadrmas Julie L, Cattrell Anna, Ruggeri Barbara, Charoen Pimphen, Lemaitre Hervé, Banaschewski Tobias, Büchel Christian, Bokde Arun L W, Carvalho Fabiana, Conrod Patricia J, Flor Herta, Frouin Vincent, Gallinat Jürgen, Garavan Hugh, Gowland Penny A, Heinz Andreas, Ittermann Bernd, Lathrop Mark, Lubbe Steven, Martinot Jean-Luc, Paus Tomás, Smolka Michael N, Spanagel Rainer, O'Reilly Paul F, Laitinen Jaana, Veijola Juha M, Feng Jianfeng, Desrivières Sylvane, Jarvelin Marjo-Riitta, Schumann Gunter, Rothenfluh Adrian
Abstract excerpt
Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adult nervous system for normal sensitivity and that it acts downstream of the integrin cell adhesion molecule and...
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