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Article

Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.

Cell - 29 May 2009

Corl Ammon B, Berger Karen H, Ophir-Shohat Galit, Gesch Julie, Simms Jeffrey A, Bartlett Selena E, Heberlein Ulrike

Abstract excerpt

The consequences of alcohol use disorders (AUDs) are devastating to individuals and society, yet few treatments are currently available. To identify genes regulating the behavioral effects of ethanol, we conducted a genetic screen in Drosophila and identified a mutant, happyhour (hppy), due to its increased resistance to the sedative effects of ethanol. Hppy protein shows strong homology to mammalian Ste20 family...

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Identifiers

PMID: 19464045
DOI: 10.1016/j.cell.2009.03.020

Genes

EGFR
EGF
GCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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