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Article

Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.

Nature neuroscience - 1 Mar 2005

Hanchar H Jacob, Dodson Paul D, Olsen Richard W, Otis Thomas S, Wallner Martin

Abstract excerpt

Neuronal mechanisms underlying alcohol intoxication are unclear. We find that alcohol impairs motor coordination by enhancing tonic inhibition mediated by a specific subtype of extrasynaptic GABA(A) receptor (GABAR), alpha6beta3delta, expressed exclusively in cerebellar granule cells. In recombinant studies, we characterize a naturally occurring single-nucleotide polymorphism that causes a single amino acid...

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Identifiers

PMID: 15696164
DOI: 10.1038/nn1398
PMCID: PMC2854077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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