Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance.

Abstract excerpt

The molecular mechanisms occurring in the nervous system that underlie behavioral responses to ethanol remain poorly understood. Here, we report that molecular requirements for two of these responses, initial sensitivity and the development of rapid tolerance, comap to the same small set of neurons. We show that null homer mutant flies exhibit both increased sensitivity to the sedative effects of ethanol and...

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