Article
Population pharmacokinetic analysis of tacrolimus in Mexican paediatric renal transplant patients: role of CYP3A5 genotype and formulation.
British journal of clinical pharmacology - 1 Oct 2015
Jacobo-Cabral Carlos Orlando, García-Roca Pilar, Romero-Tejeda Elba Margarita, Reyes Herlinda, Medeiros Mara, Castañeda-Hernández Gilberto, Trocóniz Iñaki F
Abstract excerpt
AIMS: The aims of this study were (i) to develop a population pharmacokinetic (PK) model of tacrolimus in a Mexican renal transplant paediatric population (n = 53) and (ii) to test the influence of different covariates on its PK properties to facilitate dose individualization. METHODS: Population PK and variability parameters were estimated from whole blood drug concentration profiles obtained at steady-state...
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