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Article

Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients.

British journal of clinical pharmacology - 1 Jan 2014

Jalil Mariam H Abdel, Hawwa Ahmed F, McKiernan Patrick J, Shields Michael D, McElnay James C

Abstract excerpt

AIMS: To build a population pharmacokinetic model that describes the apparent clearance of tacrolimus and the potential demographic, clinical and genetically controlled factors that could lead to inter-patient pharmacokinetic variability within children following liver transplantation. METHODS: The present study retrospectively examined tacrolimus whole blood pre-dose concentrations (n = 628) of 43 children...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23738951
DOI: 10.1111/bcp.12174
PMCID: PMC3895354

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