Article
Association Study of N-Methyl-D-Aspartate Receptor Subunit 2B (GRIN2B) Polymorphisms and Schizophrenia Symptoms in the Han Chinese Population.
PloS one - 1 Jan 2015
Yang Yongfeng, Li Wenqiang, Zhang Hongxing, Yang Ge, Wang Xiujuan, Ding Minli, Jiang Tianzi, Lv Luxian
Abstract excerpt
Schizophrenia (SZ) is a common and complex psychiatric disorder that has a significant genetic component. The glutamatergic system is the major excitatory neurotransmitter system in the central nervous system, and is mediated by N-methyl-D-aspartate (NMDA) receptors. Disturbances in this system have been hypothesized to play a major role in SZ pathogenesis. Several studies have revealed that the NMDA receptor...
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