Article
Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide.
Brain research - 29 Nov 2006
Ke Li, Qi Zhang Yu, Ping Yu, Ren Cheng Yi
Abstract excerpt
OBJECTIVE: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. Here, an A-G single nucleotide polymorphism (SNP) at the position 40237 relative to 5'-end of TPH2 gene was selected for the association with suicide behavior. METHODS: The study...
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