Article
Association between tryptophan hydroxylase 2 gene polymorphism and completed suicide.
Suicide & life-threatening behavior - 1 Dec 2010
Fudalej Sylwia, Ilgen Mark, Fudalej Marcin, Kostrzewa Grazyna, Barry Kristen, Wojnar Marcin, Krajewski Pawel, Blow Frederic, Ploski Rafal
Abstract excerpt
The association between suicide and a single nucleotide polymorphism (rs1386483) was examined in the recently identified tryptophan hydroxylase 2 (TPH2) gene. Blood samples of 143 suicide victims and 162 age- and sex-matched controls were examined. The frequency of the TT genotype in the TPH2 polymorphism was higher in suicide victims than in controls (17.5% vs. 8.6%; p = 0.02), particularly in those with a...
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