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Article

Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice.

Alcoholism, clinical and experimental research - 1 Oct 2006

Fernandez Elizabeth, Koek Wouter, Ran Qitao, Gerhardt Greg A, France Charles P, Strong Randy

Abstract excerpt

BACKGROUND: It is widely accepted that, in addition to removing acetaldehyde produced during the metabolism of ethanol, mitochondrial aldehyde dehydrogenase (ALDH2) functions in the pathway by which aldehyde metabolites of the monoamines dopamine (DA) and serotonin (5-HT) are converted to their acidic metabolites. Moreover, studies of ALDH2 inhibitors used for treating alcoholism suggest that their...

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Source

Identifiers

PMID: 17010132
DOI: 10.1111/j.1530-0277.2006.00200.x

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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